STAT5 inhibitor 17f ( STAT5-IN-17f )

Catalog No. M13355 CAS No. 2111834-61-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

STAT5 inhibitor 17f
Note

Research use only, not for human use.
Brief Description

A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation.
Description

A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation; inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5; inhibits KU812 and K562 cell growth with IC50 of 9 and 5 uM, respectively, demonstrates highly potent antileukemic effect with minimal effects on bone marrow stromal cells.
Synonyms

STAT5-IN-17f
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

——
Indication

——

CAS Number

2111834-61-6
Formula Weight

397.52
Molecular Formula

C26H27N3O
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1(C)CCN(CCOC2=CC3=C(NC=C3)C=C2)C4=C1C=C(C5=CC=CN=C5)C=C4
Chemical Name

1-(2-((1H-Indol-5-yl)oxy)ethyl)-4,4-dimethyl-6-(pyridin-3-yl)-1,2,3,4-tetrahydroquinoline

1. Juen L, et al. J Med Chem. 2017 Jul 27;60(14):6119-6136.

Calculator

molnova catalog